Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF

被引：37

作者：

Agoulnik, IY

Cho, Y

Niederberger, C

Kieback, DG

Cooney, AJ

机构：

[1] Dept Obstet & Gynecol, Houston, TX 77005 USA

[2] Univ Illinois, Dept Urol, Chicago, IL 60612 USA

[3] Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

来源：

FEBS LETTERS | 1998年 / 424卷 / 1-2期

关键词：

orphan receptor; germ cell nuclear factor;

D O I：

10.1016/S0014-5793(98)00142-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily. We report the cloning of a cDNA encoding a nem variant of human GCNF from human testis and its expression analysis. Southern blot analysis of the human genomic DNA indicates that the GCNF gene is not closely related to other members within the nuclear receptor superfamily. Chromosomal localization of the GCNF shows that the gene is located on chromosome 9 at the locus q33-34.1. In situ hybridization analysis of GCNF expression in the testis shows that human GCNF is expressed exclusively in germ cells. (C) 1998 Federation of European Biochemical Societies.

引用

页码：73 / 78

页数：6

共 34 条

[11] xGCNF, a nuclear orphan receptor is expressed during neurulation in Xenopus laevis
Joos, TO
David, R
Dreyer, C
[J]. MECHANISMS OF DEVELOPMENT, 1996, 60 (01) : 45 - 57
[12] cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF)
Kapelle, M
Kratzschmar, J
Husemann, M
Schleuning, WD
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1997, 1352 (01): : 13 - 17
[13] NONSTEROID NUCLEAR RECEPTORS - WHAT ARE GENETIC-STUDIES TELLING US ABOUT THEIR ROLE IN REAL-LIFE
KASTNER, P
MARK, M
CHAMBON, P
[J]. CELL, 1995, 83 (06) : 859 - 869
[14] Characterization of germ cell-specific expression of the orphan nuclear receptor, germ cell nuclear factor
Katz, D
Niederberger, C
Slaughter, GR
Cooney, AJ
[J]. ENDOCRINOLOGY, 1997, 138 (10) : 4364 - 4372
[15] Kleene KC, 1996, MOL REPROD DEV, V43, P268, DOI 10.1002/(SICI)1098-2795(199602)43:2&lt
[16] 268::AID-MRD17&gt
[17] 3.0.CO
[18] 2-#
[19] NUCLEAR RECEPTORS - LONESOME ORPHANS
LAUDET, V
ADELMANT, G
[J]. CURRENT BIOLOGY, 1995, 5 (02) : 124 - 127
[20] EVOLUTION OF THE NUCLEAR RECEPTOR GENE SUPERFAMILY
LAUDET, V
HANNI, C
COLL, J
CATZEFLIS, F
STEHELIN, D
[J]. EMBO JOURNAL, 1992, 11 (03) : 1003 - 1013

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