Acute SSRI administration affects the processing of social cues in healthy volunteers

被引:322
作者
Harmer, CJ [1 ]
Bhagwagar, Z
Perrett, DI
Völlm, BA
Cowen, PJ
Goodwin, GM
机构
[1] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England
[2] Univ St Andrews, Sch Psychol, St Andrews, Fife, Scotland
关键词
selective serotonin reuptake inhibitor; antidepressant; citalopram; facial expressions; emotion;
D O I
10.1038/sj.npp.1300004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. This response forms the major evidence for the role of serotonin in affective and social behaviour in humans. The present study investigated the effects of acute administration of the selective serotonin reuptake inhibitor (SSRI), citalopram ( 10 mg, i.v.) upon a measure of emotional processing in healthy female volunteers. Subjects completed a facial expression recognition task following infusion of citalopram or saline (between-subjects design, double-blind). Facial expressions associated with five basic emotions-happiness, sadness, fearfulness, anger and disgust-were displayed. Each face had been 'morphed' between neutral (0%) and each emotional standard (100%) in 10% steps, leading to a range of emotional intensities. Mood and subjective experience were also monitored throughout the testing session. Volunteers receiving citalopram detected a higher number of facial expressions of fear and happiness, with reduced response times, relative to those given the placebo. By contrast, changes in the recognition of other basic emotions were not observed following citalopram. Notable differences in mood were also not apparent in these volunteers. These results suggest that acute administration of antidepressant drugs may affect neural processes involved in the processing of social information. This effect may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions.
引用
收藏
页码:148 / 152
页数:5
相关论文
共 39 条
  • [1] Recognition of facial emotion in nine individuals with bilateral amygdala damage
    Adolphs, R
    Tranel, D
    Hamann, S
    Young, AW
    Calder, AJ
    Phelps, EA
    Anderson, A
    Lee, GP
    Damasio, AR
    [J]. NEUROPSYCHOLOGIA, 1999, 37 (10) : 1111 - 1117
  • [2] IMPAIRED RECOGNITION OF EMOTION IN FACIAL EXPRESSIONS FOLLOWING BILATERAL DAMAGE TO THE HUMAN AMYGDALA
    ADOLPHS, R
    TRANEL, D
    DAMASIO, H
    DAMASIO, A
    [J]. NATURE, 1994, 372 (6507) : 669 - 672
  • [3] Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat
    Amat, J
    Matus-Amat, P
    Watkins, LR
    Maier, SF
    [J]. BRAIN RESEARCH, 1998, 812 (1-2) : 113 - 120
  • [4] Attenburrow MJ, 2001, PSYCHOPHARMACOLOGY, V155, P323
  • [5] FLUOXETINE - A REVIEW OF RECEPTOR AND FUNCTIONAL-EFFECTS AND THEIR CLINICAL IMPLICATIONS
    BEASLEY, CM
    MASICA, DN
    POTVIN, JH
    [J]. PSYCHOPHARMACOLOGY, 1992, 107 (01) : 1 - 10
  • [6] Selective impairment in the recognition of anger induced by diazepam
    Blair, RJR
    Curran, HV
    [J]. PSYCHOPHARMACOLOGY, 1999, 147 (03) : 335 - 338
  • [7] CURRENT ADVANCES AND TRENDS IN THE TREATMENT OF DEPRESSION
    BLIER, P
    DEMONTIGNY, C
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) : 220 - 226
  • [8] Depressed patients' perceptions of facial emotions in depressed and remitted states are associated with relapse - A longitudinal study
    Bouhuys, AL
    Geerts, E
    Gordijn, MCM
    [J]. JOURNAL OF NERVOUS AND MENTAL DISEASE, 1999, 187 (10) : 595 - 602
  • [9] Face processing impairments after encephalitis: amygdala damage and recognition of fear
    Broks, P
    Young, AW
    Maratos, EJ
    Coffey, PJ
    Calder, AJ
    Isaac, CL
    Mayes, AR
    Hodges, JR
    Montaldi, D
    Cezayirli, E
    Roberts, N
    Hadley, D
    [J]. NEUROPSYCHOLOGIA, 1998, 36 (01) : 59 - 70
  • [10] Impaired recognition and experience of disgust following brain injury
    Calder, AJ
    Keane, J
    Manes, F
    Antoun, N
    Young, AW
    [J]. NATURE NEUROSCIENCE, 2000, 3 (11) : 1077 - 1078