Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

被引：12

作者：

Chen, SH ^{[1
]}

Sun, XC ^{[1
]}

Boyer, R ^{[1
]}

Paschal, J ^{[1
]}

Zeckner, D ^{[1
]}

Current, W ^{[1
]}

Zweifel, M ^{[1
]}

Rodriguez, M ^{[1
]}

机构：

[1] Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)00424-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2107 / 2110

页数：4

共 8 条

[1] Balkovec J. M., 1998, ANNU REP MED CHEM, V33, P173
[2] NOVEL BIOACTIVE LIPODEPSIPEPTIDES FROM PSEUDOMONAS-SYRINGAE - THE PSEUDOMYCINS
BALLIO, A
BOSSA, F
DIGIORGIO, D
FERRANTI, P
PACI, M
PUCCI, P
SCALONI, A
SEGRE, A
STROBEL, GA
[J]. FEBS LETTERS, 1994, 355 (01) : 96 - 100
[3] ASYMMETRIC-SYNTHESIS VIA ACETAL TEMPLATES .3. ON THE STEREOCHEMISTRY OBSERVED IN THE CYCLIZATION OF CHIRAL ACETALS OF POLYOLEFINIC ALDEHYDES - FORMATION OF OPTICALLY-ACTIVE HOMOALLYLIC ALCOHOLS
BARTLETT, PA
JOHNSON, WS
ELLIOTT, JD
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (07) : 2088 - 2089
[4] New azole antifungals.: 3.: Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones
Bartroli, J
Turmo, E
Algueró, M
Boncompte, E
Vericat, ML
Conte, L
Ramis, J
Merlos, M
García-Rafanell, J
Forn, J
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (11) : 1869 - 1882
[5] Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1
Jamison, J
Levy, S
Sun, XC
Zeckner, D
Current, W
Zweifel, M
Rodriguez, M
Turner, W
Chen, SH
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (18) : 2101 - 2105
[6] KERRIDGE D, 1992, ANTIFUNGAL THERAPY A, P1
[7] RODRIGUEZ M, 2000, UNPUB BIOORG MED CHE
[8] Vandeputte J., 1956, ANTIBIOT ANNU, P587

← 1 →