Sphingosine-1-phosphate stimulates cortisol secretion

被引：35

作者：

Rábano, M ^{[1
]}

Peña, A ^{[1
]}

Brizuela, L ^{[1
]}

Marino, A ^{[1
]}

Macarulla, JM ^{[1
]}

Trueba, M ^{[1
]}

Gómez-Muñoz, A ^{[1
]}

机构：

[1] Univ Basque Country, Fac Sci, Dept Biochem & Mol Biol, Bilbao 48080, Spain

来源：

FEBS LETTERS | 2003年 / 535卷 / 1-3期

关键词：

sphingosine-1-phosphate; ceramide; cortisol secretion; phospholipase D; protein kinase C; adrenal gland;

D O I：

10.1016/S0014-5793(02)03882-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show here for the first time that sphingosine-1-phosphate (Sph-1-P) stimulates cortisol secretion in zona fasciculata cells of bovine adrenal glands. This effect was dependent upon protein kinase C (PKC) and extracellular Ca2+, and was inhibited by pertussis toxin. Sph-1-P activated phospholipase D (PLD) through a pertussis toxin-sensitive mechanism, also involving extracellular Ca2+ and PKC. Primary alcohols, which attenuate formation of phosphatidic acid (the product of PLD), and cell-permeable ceramides, which inhibit PLD, blocked Sph-1-P-induced cortisol secretion. In conclusion, Sph-1-P stimulates cortisol secretion through a mechanism involving Gi/o protein-coupled receptors, extracellular Ca2+, PKC and PLD. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：101 / 105

页数：5

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