Sphingosine-1-phosphate stimulates cortisol secretion

被引：35

作者：

Rábano, M ^{[1
]}

Peña, A ^{[1
]}

Brizuela, L ^{[1
]}

Marino, A ^{[1
]}

Macarulla, JM ^{[1
]}

Trueba, M ^{[1
]}

Gómez-Muñoz, A ^{[1
]}

机构：

[1] Univ Basque Country, Fac Sci, Dept Biochem & Mol Biol, Bilbao 48080, Spain

来源：

FEBS LETTERS | 2003年 / 535卷 / 1-3期

关键词：

sphingosine-1-phosphate; ceramide; cortisol secretion; phospholipase D; protein kinase C; adrenal gland;

D O I：

10.1016/S0014-5793(02)03882-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show here for the first time that sphingosine-1-phosphate (Sph-1-P) stimulates cortisol secretion in zona fasciculata cells of bovine adrenal glands. This effect was dependent upon protein kinase C (PKC) and extracellular Ca2+, and was inhibited by pertussis toxin. Sph-1-P activated phospholipase D (PLD) through a pertussis toxin-sensitive mechanism, also involving extracellular Ca2+ and PKC. Primary alcohols, which attenuate formation of phosphatidic acid (the product of PLD), and cell-permeable ceramides, which inhibit PLD, blocked Sph-1-P-induced cortisol secretion. In conclusion, Sph-1-P stimulates cortisol secretion through a mechanism involving Gi/o protein-coupled receptors, extracellular Ca2+, PKC and PLD. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：101 / 105

页数：5

共 33 条

[21] AN UPDATE OF THE ENZYMOLOGY AND REGULATION OF SPHINGOMYELIN METABOLISM [J].

MERRILL, AH ;

JONES, DD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1044 (01) :1-12

[22] SPHINGOSINE-1-PHOSPHATE AS 2ND MESSENGER IN CELL-PROLIFERATION INDUCED BY PDGF AND FCS MITOGENS [J].

OLIVERA, A ;

SPIEGEL, S .

NATURE, 1993, 365 (6446) :557-560

[23] Sphingosine-1-phosphate: dual messenger functions [J].

Payne, SG ;

Milstien, S ;

Spiegel, S .

FEBS LETTERS, 2002, 531 (01) :54-57

[24] Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini [J].

Pérez-Andrés, E ;

Fernández-Rodriguez, M ;

González, M ;

Zubiaga, A ;

Vallejo, A ;

García, I ;

Matute, C ;

Pochet, S ;

Dehaye, JP ;

Trueba, M ;

Marino, A ;

Gómez-Muñoz, A .

JOURNAL OF LIPID RESEARCH, 2002, 43 (08) :1244-1255

[25] DIACYLGLYCEROL PRODUCTION, CA2+ INFLUX, AND PROTEIN-KINASE-C ACTIVATION IN SUSTAINED CELLULAR-RESPONSES [J].

RASMUSSEN, H ;

ISALES, CM ;

CALLE, R ;

THROCKMORTON, D ;

ANDERSON, M ;

GASALLAHERRAIZ, J ;

MCCARTHY, R .

ENDOCRINE REVIEWS, 1995, 16 (05) :649-681

[26] DIFFERENTIAL ROLES OF DE-NOVO SPHINGOLIPID BIOSYNTHESIS AND TURNOVER IN THE BURST OF FREE SPHINGOSINE AND SPHINGANINE, AND THEIR 1-PHOSPHATES AND N-ACYL-DERIVATIVES, THAT OCCURS UPON CHANGING THE MEDIUM OF CELLS IN CULTURE [J].

SMITH, ER ;

MERRILL, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (32) :18749-18758

[27] Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases [J].

Smith, ER ;

Jones, PL ;

Boss, JM ;

Merrill, AH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) :5640-5646

[28] Raf-1 kinase activation by angiotensin II in adrenal glomerulosa cells:: Roles of Gi, phosphatidylinositol 3-kinase, and Ca2+ influx [J].

Smith, RD ;

Baukal, AJ ;

Dent, P ;

Catt, KJ .

ENDOCRINOLOGY, 1999, 140 (03) :1385-1391

[29] Sphingosine 1-phosphate, a key cell signaling molecule. [J].

Spiegel, S ;

Milstien, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) :25851-25854

[30]

STUNFF HL, 2000, MOL PHARM, V292, P629

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