Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

被引：88

作者：

Bailey, Leslie

Gylfe, Asa

Sundin, Charlotta

Muschiol, Sandra

Elofsson, Mikael

Nordstrom, Peter

Henriques-Normark, Birgitta

Lugert, Raimond

Waldenstrom, Anders

Wolf-Watz, Hans

Bergstrom, Sven ^{[1
]}

机构：

[1] Umea Univ, Dept Mol Biol, SE-90187 Umea, Sweden

[2] Karolinska Inst, Swedish Inst Infect Dis Control & Microbiol, SE-1782 Stockholm, Sweden

[3] Karolinska Inst, Tumor Biol Ctr, SE-1782 Stockholm, Sweden

[4] Umea Univ, Dept Chem, SE-90347 Umea, Sweden

[5] Umea Univ, Dept Internal Med, SE-90187 Umea, Sweden

[6] Univ Gottingen, Dept Bacteriol, D-37075 Gottingen, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 04期

关键词：

type III secretion; inhibitors; chemical genetics; Chlamydia; Yersinia;

D O I：

10.1016/j.febslet.2007.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular parasitism by Chlainydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated. p in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaidehydes that specifically blocks the T3S of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlaniydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：587 / 595

页数：9

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