MgO nanoparticle-based multifunctional catalysts in the cascade reaction allows the green synthesis of anti-inflammatory agents

被引:102
作者
Climent, Maria Jose [1 ]
Corma, Avelino [1 ]
Iborra, Sara [1 ]
Mifsud, Maria [1 ]
机构
[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Valencia 46022, Spain
关键词
aldol condensation; anti-inflammatory; cascade reaction; MgO; multifunctional catalyst;
D O I
10.1016/j.jcat.2007.02.003
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Up to now, the anti-inflammatory agent nabumetone has been synthesized by a two-step process involving either a Heck reaction between 6-bromo-2-methoxynaphthalene and methyl vinyl ketone or a condensation between 6-methoxy-2 naphthaldehyde and acetone to give an intermediate that is separated, purified, and hydrogenated in a second and separate process to give the final product, while producing a large amount of waste products. Here we report a residue-free catalytic process for the production of nabumetone with >= 98% yield and 100% selectivity achieved through a cascade reaction system involving a multifunctional base/acid/hydrogenation catalyst based on nanocrystalline (-3 nm) MgO. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:223 / 230
页数:8
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