Oxidized proteins: Intracellular distribution and recognition by the proteasome

被引：71

作者：

Jung, Tobias

Bader, Nicolle

Grune, Tilman ^{[1
]}

机构：

[1] Univ Dusseldorf, Environm Med Res Inst, D-4000 Dusseldorf, Germany

[2] Univ Hohenheim, Inst Biol Chem & Nutr, D-70593 Stuttgart, Germany

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2007年 / 462卷 / 02期

关键词：

protein oxidation; protein carbonyl formation; protein nitration; proteasome;

D O I：

10.1016/j.abb.2007.01.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The formation of oxidized proteins is one of the highlights of oxidative stress. In order not to accumulate such proteins have to be degraded. The major proteolytic system responsible for the removal of oxidized proteins is the proteasome. The proteasome is distributed throughout the cytosolic and nuclear compartment of mammalian cells, with high concentrations in the nucleus. On the other hand a major part of protein oxidation is taking place in the cytosol. The present review highlights the current knowledge on the intracellular distribution of oxidized proteins and put it into contrast with the concentration and distribution of the proteasome. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：231 / 237

页数：7

共 85 条

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