Bluetongue virus VP4 is an RNA-capping assembly line

被引：66

作者：

Sutton, Geoff

Grimes, Jonathan M.

Stuart, David I.

Roy, Polly

机构：

[1] Univ Oxford, Div Struct Biol, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 05期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nsmb1225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

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页码：449 / 451

页数：3

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