HPLC Studio:: A novel software utility to perform HPLC chromatogram comparison for screening purposes

被引：6

作者：

García, JB ^{[1
]}

Tormo, JR ^{[1
]}

机构：

[1] Merck Sharp & Dohme Espana, CIBE, Madrid 20253, Spain

来源：

JOURNAL OF BIOMOLECULAR SCREENING | 2003年 / 8卷 / 03期

关键词：

HPLC Studio; high-performance liquid chromatography; software tools; virtual chromatogram;

D O I：

10.1177/1087057103008003008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new tool, HPLC Studio, was developed for the comparison of high-performance liquid chromatography (HPLC) chromatograms, from microbial extracts. The new utility makes it possible to create a virtual chromatogram by mixing up to 20 individual chromatograms. The virtual chromatogram is the first step in establishing a ranking of the microbial fermentation conditions based on either the area or diversity of HPLC peaks. The utility was used to maximize the diversity of secondary metabolites tested from a microorganism and therefore increase the chances of finding new lead compounds in a drug discovery program. (Journal of Biomolecular Screening 2003:305-315).

引用

页码：305 / 315

页数：11

共 13 条

[1] High-performance liquid chromatographic separation of the impurities in a pharmaceutical raw material with the aid of computer simulation [J].