Extracellular levels of neuropeptide Y are markedly increased in the dorsal hippocampus of freely moving rats during kainic acid-induced seizures

被引：23

作者：

Husum, H ^{[1
]}

Mikkelsen, JD ^{[1
]}

Mork, A ^{[1
]}

机构：

[1] H Lundbeck AS, Dept Neurobiol, DK-2500 Copenhagen, Denmark

来源：

BRAIN RESEARCH | 1998年 / 781卷 / 1-2期

关键词：

neuropeptide Y; microdialysis; seizure; rat; dorsal hippocampus; kainic acid;

D O I：

10.1016/S0006-8993(97)01374-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this microdialysis study we measured the extracellular neuropeptide Y (NPY) levels in the dorsal hippocampus of conscious rats. During potassium-induced depolarisations, a 93% increase in extracellular levels of NPY was observed. NPY has been demonstrated to reduce kainic acid-induced convulsions in rats, but it is unknown whether NPY neurotransmission is affected by seizures. During seizures induced by kainic acid we observed a 104% increase in levels of NPY, suggesting that convulsions are associated with a dramatically increased NPYergic neurotransmission. (C) 1998 Elsevier Science B.V.

引用

页码：351 / 354

页数：4

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