Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia gyandilobata

被引：31

作者：

Ahmed, Atallah F.

Tai, Shu-Hui

Wu, Yang-Chang

Sheu, Jyh-Horng ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Univ Mansoura, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[4] Natl Sun Yat Sen Univ, Asian Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

STEROIDS | 2007年 / 72卷 / 04期

关键词：

trihydroxysteroids; Sinularia grandilobata; cytotoxicity;

D O I：

10.1016/j.steroids.2007.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new trihydroxysteroids, sinugrandisterols A-D (1-4), have been isolated from the CH2Cl2-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：368 / 374

页数：7

共 17 条

[1] 1α,3β,5β-Trihydroxy-24-methylenecholestan-6-one:: a novel steroid from a soft coral Sinularia gibberosa [J].