Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

被引：61

作者：

Chen, B

Petukhov, PA

Jung, M

Velena, A

Eliseeva, E

Dritschilo, A

Kozikowski, AP

机构：

[1] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[2] Georgetown Univ, Dept Radiat Med, Washington, DC 20057 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 05期

关键词：

histone deacetylase inhibitor; HDAC; mercaptoacetamide;

D O I：

10.1016/j.bmcl.2005.01.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1389 / 1392

页数：4

共 27 条

[1]

*ACC INC, 2002, INS 2

[2] Histone acetylation and cancer [J].