Nuclear localization and function of polypeptide ligands and their receptors: a new paradigm for hormone specificity within the mammary gland?

被引：24

作者：

Clevenger, CV ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

BREAST CANCER RESEARCH | 2003年 / 5卷 / 04期

关键词：

cyclophilin; retrotransport; signal transduction; Stat5; transcription;

D O I：

10.1186/bcr601

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The specific effects triggered by polypeptide hormone/growth factor stimulation of mammary cells were considered mediated solely by receptor-associated signaling networks. A compelling body of new data, however, clearly indicates that polypeptide ligands and/or their receptors are transported into the nucleus, where they function directly to regulate the expression of specific transcription factors and gene loci. The intranuclear function of these complexes may contribute to the explicit functions associated with a given ligand, and may serve as new targets for pharmacologic intervention.

引用

页码：181 / 187

页数：7

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