Absolute stereochemistry of halichlorine; A potent inhibitor of VCAM-1 induction

被引:87
作者
Arimoto, H
Hayakawa, I
Kuramoto, M
Uemura, D
机构
[1] Shizuoka Univ, Fac Sci, Dept Chem, Shizuoka 422, Japan
[2] Ehime Univ, Adv Instrumentat Ctr Chem Anal, Matsuyama, Ehime 79077, Japan
[3] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 46401, Japan
关键词
D O I
10.1016/S0040-4039(97)10714-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The absolute stereochemistry of a marine alkaloid halichlorine, which significantly inhibits VCAM-1 induction in HUVE cells, was established by synthesis of a degradation product of natural product. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:861 / 862
页数:2
相关论文
共 4 条
  • [1] Pinnaic acid and tauropinnaic acid: Two novel fatty acids composing a 6-Azaspiro[4.5]decane unit from the Okinawan bivalve Pinna muricata
    Chou, T
    Kuramoto, M
    Otani, Y
    Shikano, M
    Yazawa, K
    Uemura, D
    [J]. TETRAHEDRON LETTERS, 1996, 37 (22) : 3871 - 3874
  • [2] Halichlorine, an inhibitor of VCAM-1 induction from the marine sponge Halichondria okadai Kadota
    Kuramoto, M
    Tong, C
    Yamada, K
    Chiba, T
    Hayashi, Y
    Uemura, D
    [J]. TETRAHEDRON LETTERS, 1996, 37 (22) : 3867 - 3870
  • [3] TAKANO S, 1994, SYNLETT, P119
  • [4] YADAV JS, 1988, TETRAHEDRON LETT, V29, P2737