Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?

被引：190

作者：

Voss, Michelle W. ^{[1
,2
]}

Erickson, Kirk I. ^{[4
]}

Prakash, Ruchika S. ^{[1
,2
]}

Chaddock, Laura ^{[1
,2
]}

Malkowski, Edward ^{[1
,2
]}

Alves, Heloisa ^{[1
,2
]}

Kim, Jennifer S. ^{[1
,2
]}

Morris, Katherine S. ^{[3
]}

White, Siobhan M. ^{[3
]}

Wojcicki, Thomas R. ^{[3
]}

Hu, Liang ^{[3
]}

Szabo, Amanda ^{[3
]}

Klamm, Emily ^{[3
]}

McAuley, Edward ^{[3
]}

Kramer, Arthur F. ^{[1
,2
]}

机构：

[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA

[4] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

NEUROPSYCHOLOGIA | 2010年 / 48卷 / 05期

关键词：

Cognitive aging; fMRI; Functional connectivity; Aerobic exercise; Executive function; Spatial memory; RESTING-STATE NETWORKS; DEFAULT-MODE; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; CORTICAL PLASTICITY; PHYSICAL-ACTIVITY; BRAIN ACTIVITY; DENTATE GYRUS; MOTOR CORTEX; OLDER-ADULTS;

D O I：

10.1016/j.neuropsychologia.2010.01.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer's disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1394 / 1406

页数：13

共 84 条

[11] Memory for events and their spatial context: models and experiments [J].

Burgess, N ;

Becker, S ;

King, JA ;

O'Keefe, J .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 356 (1413) :1493-1503

[12] Remembering the past and imagining the future: A neural model of spatial memory and imagery [J].

Byrne, Patrick ;

Becker, Suzanna ;

Burgess, Neil .

PSYCHOLOGICAL REVIEW, 2007, 114 (02) :340-375

[13] Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes [J].

Castelli, Fulvia ;

Frith, Chris ;

Happe, Francesca ;

Frith, Uta .

BRAIN, 2002, 125 :1839-1849

[14] Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: An independent component analysis [J].

Celone, Kim A. ;

Calhoun, Vince D. ;

Dickerson, Bradford C. ;

Atri, Alireza ;

Chua, Elizabeth F. ;

Miller, Saul L. ;

DePeau, Kristina ;

Rentz, Doreen M. ;

Selkoe, Dennis J. ;

Blacker, Deborah ;

Albert, Marilyn S. ;

Sperling, Reisa A. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (40) :10222-10231

[15] Effects of model-based physiological noise correction on default mode network anti-correlations and correlations [J].

Chang, Catie ;

Glover, Gary H. .

NEUROIMAGE, 2009, 47 (04) :1448-1459

[16] Exercising our brains: How physical activity impacts synaptic plasticity in the dentate gyrus [J].

Christie, Brian R. ;

Eadie, Brennan D. ;

Kannangara, Timal S. ;

Robillard, Julie M. ;

Shin, James ;

Titterness, Andrea K. .

NEUROMOLECULAR MEDICINE, 2008, 10 (02) :47-58

[17] Functional Analysis of Neurovascular Adaptations to Exercise in the Dentate Gyrus of Young Adult Mice Associated With Cognitive Gain [J].

Clark, Peter J. ;

Brzezinska, Weronika J. ;

Puchalski, Emily K. ;

Krone, David A. ;

Rhodes, Justin S. .

HIPPOCAMPUS, 2009, 19 (10) :937-950

[18] Fitness effects on the cognitive function of older adults: A meta-analytic study [J].

Colcombe, S ;

Kramer, AF .

PSYCHOLOGICAL SCIENCE, 2003, 14 (02) :125-130

[19] Cardiovascular fitness, cortical plasticity, and aging [J].

Colcombe, SJ ;

Kramer, AF ;

Erickson, KI ;

Scalf, P ;

McAuley, E ;

Cohen, NJ ;

Webb, A ;

Jerome, GJ ;

Marquez, DX ;

Elavsky, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :3316-3321

[20] Aerobic exercise training increases brain volume in aging humans [J].

Colcombe, Stanley J. ;

Erickson, Kirk I. ;

Scalf, Paige E. ;

Kim, Jenny S. ;

Prakash, Ruchika ;

McAuley, Edward ;

Elavsky, Steriani ;

Marquez, David X. ;

Hu, Liang ;

Kramer, Arthur F. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (11) :1166-1170

← 1 2 3 4 5 6 7 8 9 →