High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa

被引：14

作者：

Nie, Y

Xu, Y ^{[1
]}

Mu, XQ

Tang, Y

Jiang, J

Sun, ZH

机构：

[1] So Yangtze Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214036, Peoples R China

[2] So Yangtze Univ, Sch Biotechnol, Wuxi 214036, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2005年 / 27卷 / 01期

基金：

中国国家自然科学基金;

关键词：

2-octanol; enantioselective conversion; microbial stereoinversion;

D O I：

10.1007/s10529-004-6310-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Whole cells of Candida rugosa catalyzed the conversion of (R)-2-octanol from the corresponding racemate with the optical purity of 97% e.e. and yield of 92% in 10 h. The product was formed through a stereoinversion involving enantioselective oxidation and asymmetric reduction with 2-octanone as the intermediate.

引用

页码：23 / 26

页数：4