A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

被引：228

作者：

Bruenn, JA ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA

[2] Hauptman Woodward Med Res Inst, Buffalo, NY 14203 USA

来源：

NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1093/nar/gkg277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.

引用

收藏

页码：1821 / 1829

页数：9

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