A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

被引：228

作者：

Bruenn, JA ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA

[2] Hauptman Woodward Med Res Inst, Buffalo, NY 14203 USA

来源：

NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1093/nar/gkg277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.

引用

收藏

页码：1821 / 1829

页数：9

相关论文

共 110 条

[11] RELATIONSHIPS AMONG THE POSITIVE STRAND AND DOUBLE-STRAND RNA VIRUSES AS VIEWED THROUGH THEIR RNA-DEPENDENT RNA-POLYMERASES [J].

BRUENN, JA .

NUCLEIC ACIDS RESEARCH, 1991, 19 (02) :217-226

[12] A CLOSELY-RELATED GROUP OF RNA-DEPENDENT RNA-POLYMERASES FROM DOUBLE-STRANDED-RNA VIRUSES [J].

BRUENN, JA .

NUCLEIC ACIDS RESEARCH, 1993, 21 (24) :5667-5669

[13] A mechanism for initiating RNA-dependent RNA polymerization [J].

Butcher, SJ ;

Grimes, JM ;

Makeyev, EV ;

Bamford, DH ;

Stuart, DL .

NATURE, 2001, 410 (6825) :235-240

[14] RNA DUPLEX UNWINDING ACTIVITY OF POLIOVIRUS RNA-DEPENDENT RNA-POLYMERASE 3DPOL [J].

CHO, MW ;

RICHARDS, OC ;

DMITRIEVA, TM ;

AGOL, V ;

EHRENFELD, E .

JOURNAL OF VIROLOGY, 1993, 67 (06) :3010-3018

[15] RELATIONSHIPS AMONG TRIALEURODES-VAPORARIORUM - TRANSMITTED YELLOWING VIRUSES FOR EUROPE AND NORTH-AMERICA [J].

COFFIN, RS ;

COUTTS, RHA .

JOURNAL OF PHYTOPATHOLOGY-PHYTOPATHOLOGISCHE ZEITSCHRIFT, 1995, 143 (06) :375-380

[16] MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE OF THE PESTIVIRUS BOVINE VIRAL DIARRHEA VIRUS [J].

COLLETT, MS ;

LARSON, R ;

GOLD, C ;

STRICK, D ;

ANDERSON, DK ;

PURCHIO, AF .

VIROLOGY, 1988, 165 (01) :191-199

[17] Genetic interrelationships and genome organization of double-stranded RNA elements of Fusarium poae [J].

Compel, P ;

Papp, I ;

Bibó, M ;

Fekete, C ;

Hornok, L .

VIRUS GENES, 1999, 18 (01) :49-56

[18] COMPLETE NUCLEOTIDE-SEQUENCE OF ALFALFA MOSAIC-VIRUS RNA-2 [J].

CORNELISSEN, BJC ;

BREDERODE, FT ;

VEENEMAN, GH ;

VANBOOM, JH ;

BOL, JF .

NUCLEIC ACIDS RESEARCH, 1983, 11 (10) :3019-3025

[19] TOMATO SPOTTED WILT VIRUS-L RNA ENCODES A PUTATIVE RNA-POLYMERASE [J].

DEHAAN, P ;

KORMELINK, R ;

RESENDE, RD ;

VANPOELWIJK, F ;

PETERS, D ;

GOLDBACH, R .

JOURNAL OF GENERAL VIROLOGY, 1991, 72 :2207-2216

[20] AN ATTEMPT TO UNIFY THE STRUCTURE OF POLYMERASES [J].

DELARUE, M ;

POCH, O ;

TORDO, N ;

MORAS, D ;

ARGOS, P .

PROTEIN ENGINEERING, 1990, 3 (06) :461-467

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