Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent
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作者:
Georges, SA
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机构:Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Georges, SA
Giebler, HA
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机构:Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Giebler, HA
Cole, PA
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机构:Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Cole, PA
Luger, K
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机构:Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Luger, K
Laybourn, PJ
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机构:Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Laybourn, PJ
Nyborg, JK
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Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USAColorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Nyborg, JK
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[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA
Robust transcription of human T-cell leukemia virus type 1 (HTLV-1) genome requires the viral transactivator Tax. Although Tax has been previously shown to interact with the KIX domain of CBP/p300 in vitro, the precise functional relevance of this interaction remains unclear. Using two distinct approaches to interrupt the physical interaction between Tax and KIX, we find that Tax transactivation from chromatin templates is strongly dependent on CBP/p300 recruitment via the KIX domain. Additionally, we find that the primary functional contribution of CBP/p300 to Tax transactivation resides in the intrinsic acetyltransferase activity of the coactivators. These studies unexpectedly uncover a specific requirement for CBP/p300 acetyltransferase activity on chromatin templates assembled with nucleosomes lacking their amino-terminal tails. Together, these data indicate that the KIX domain of CBP/p300 is essential for targeting the acetyltransferase activity of the coactivator to the Tax-CREB (Tax/CREB) complex. Significantly, these observations reveal the presence of one or more CBP/p300 acetyltransferase targets that function specifically on chromatin templates, are independent of the histone tails, and are critical to Tax transactivation.
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Näär, AM
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Beaurang, PA
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Beaurang, PA
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Robinson, KM
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Robinson, KM
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Oliner, JD
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Oliner, JD
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Avizonis, D
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Avizonis, D
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Scheek, S
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Scheek, S
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Zwicker, J
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Zwicker, J
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Kadonaga, JT
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Kadonaga, JT
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Tjian, R
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Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Näär, AM
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Beaurang, PA
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Beaurang, PA
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Robinson, KM
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Robinson, KM
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Oliner, JD
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Oliner, JD
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Avizonis, D
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Avizonis, D
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Scheek, S
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Scheek, S
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Zwicker, J
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Zwicker, J
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Kadonaga, JT
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机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA
Kadonaga, JT
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Tjian, R
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Univ Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Howard Hughes Med Inst, Berkeley, CA 94720 USA