Recognition of 2′-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases

被引：23

作者：

Lutz, MJ

Horlacher, J

Benner, SA

机构：

[1] ETH Zurich, Dept Chem, CH-8092 Zurich, Switzerland

[2] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00057-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

HIV-1 reverse transcriptase (RT) incorporates 2'-deoxyisoguanosine triphosphate (d-isoGTP) opposite thymidine (T) in a DNA template and opposite uracil (U) in an RNA template about 10 times more efficiently than the eukaryotic DNA polymerase a, both in the absence and presence of dATP. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：499 / 504

页数：6

共 15 条

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