Asymmetric hydrogenation of the C-C double bond of enones with the reductases from Nicotiana tabacum

被引：23

作者：

Hirata, T ^{[1
]}

Shimoda, K ^{[1
]}

Gondai, T ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Sci, Dept Math & Life Sci, Higashihiroshima 7398526, Japan

来源：

CHEMISTRY LETTERS | 2000年 / 08期

关键词：

D O I：

10.1246/cl.2000.850

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three enone reductases, p44, p74, and p90, from the cultured cells of Nicotiana tabacum catalyzed the asymmetric hydrogenation of the C-C double bond of enones. Reduction of 2-alkyl-2-cyclohexen-1-ones with the p44 reductase gave highly optically active (R)-2 -alkylcyclohexanones, whereas reaction with the p90 reductase gave (S)-2-alkylcyclohexanones. On the other hand, reduction of 2-alkylidenecyclohexanones with the p74 reductase gave (S)-2-alkylcyclohexanones.

引用

页码：850 / 851

页数：2

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