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Trifluoromethylalkenes in cycloaddition reactions

被引：54
作者：
BonnetDelpon, D
Begue, JP
Lequeux, T
Ourevitch, M
机构：
[1] CNRS - BIOCIS, Centre d'Etudes Pharmaceutiques, Tour D3, 92296 Châtenay-Malabry, 5eme Et., R. J.B. Clement
来源：
TETRAHEDRON | 1996年 / 52卷 / 01期
关键词：
D O I：
10.1016/0040-4020(95)00885-C
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
CF3-Substituted alkenes have been described to be good partners in Diels-Alder reactions with the Danishefsky's diene and in 1,3-dipolar cycloadditions with nitrones and non-stabilized azomethine ylides. The influence of the CF3-group on both the activation of the double bond and the stereochemistry of the cycloaddition has been evaluated. New CF3-substituted mono- and polycyclic compounds 4 and 7, highly functionalized isoxazolidines 18, 19, 22 and 23 and pyrrolidines 12, 13 and 16 have been prepared.
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页码：59 / 70
页数：12
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