Mitochondrial control of apoptosis: an introduction

被引：241

作者：

Kroemer, G ^{[1
]}

机构：

[1] Inst Gustave Roussy, Ctr Natl Rech Sci, UMR 8125, F-94805 Villejuif, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

关键词：

Bcl-2; cancer; necrosis; neurodegeneration; programmed cell death;

D O I：

10.1016/S0006-291X(03)00614-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial membrane permeabilization [MNIP] constitutes an essential step of the intrinsic pathway leading to apoptosis. Several oncoproteins, tumor suppressor gene products, viral virulence factors and pharmacological agents modulate apoptosis via direct effects on mitochondria. This has far-reaching implications for the pathophysiology of several major diseases such as cancer, neurodegeneration, and AIDS. The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：433 / 435

页数：3

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