syn-selective catalytic asymmetric nitro-Mannich reactions using a heterobimetallic Cu-Sm-Schiff base complex

被引：217

作者：

Handa, Shinya ^{[1
]}

Gnanadesikan, Vijay ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 16期

关键词：

D O I：

10.1021/ja0701560

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

syn-Selective catalytic asymmetric nitro-Mannich reactions using a heterobimetallic Cu/Sm/Schiff base complex are described. The present method is complementary to the previously reported methods, and products were obtained in high syn-selectivity (> 20:1), yield (99-62%), and enantioselectivity (98-83% ee). Both Cu and Sm metals, aligned suitably in a dinucleating Schiff base ligand, were essential to realize high synselectivity.

引用

页码：4900 / +

页数：3

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