A semi-quantitative model for risk appreciation and risk weighing

被引:13
作者
Bos, Peter M. J. [1 ]
Boon, Polly E. [2 ]
van der Voet, Hilko [2 ]
Janer, Gemma [1 ]
Piersma, Aldert H. [1 ]
Brueschweiler, Beat J. [3 ]
Nielsen, Elsa [4 ]
Slob, Wout [1 ]
机构
[1] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands
[2] Univ Wageningen & Res Ctr, RIKILT Inst Food Safety, NL-6700 HB Wageningen, Netherlands
[3] FOPH, Zurich, Switzerland
[4] Tech Univ Denmark, Soborg, Denmark
关键词
Probabilistic risk assessment; Health impact assessment; Risk management; Risk prioritization; END-POINTS; DEOXYNIVALENOL; EXPOSURE; VOMITOXIN; LIMITS; MICE;
D O I
10.1016/j.fct.2009.03.009
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Risk managers need detailed information on (1) the type of effect. (2) the size (severity) of the expected effect(s) and (3) the fraction of the population at risk to decide on well-balanced risk reduction measures. A previously developed integrated probabilistic risk assessment (IPRA) model provides quantitative information on these three parameters. A semi-quantitative tool is presented that combines information on these parameters into easy-readable charts that will facilitate risk evaluations of exposure situations and decisions on risk reduction measures. This tool is based on a concept of health impact categorization that has been successfully in force for several years within several emergency planning programs. Four health impact categories are distinguished: No-Health Impact, Low-Health Impact, Moderate-Health Impact and Severe-Health Impact. Two different charts are presented to graphically present the information on the three parameters of interest. A bar plot provides an overview of all health effects involved, including information on the fraction of the exposed population in each of the four health impact categories. Secondly, a Health Impact Chart is presented to provide more detailed information on the estimated health impact in a given exposure situation. These graphs will facilitate the discussions on appropriate risk reduction measures to be taken. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2941 / 2950
页数:10
相关论文
共 20 条
[1]  
[Anonymous], MCRA RELEASE 6 WEB B
[2]   Effects of deoxynivalenol (DON, vomitoxin) on in utero development in rats [J].
Collins, Thomas F. X. ;
Sprando, Robert L. ;
Black, Thomas N. ;
Olejnik, Nicholas ;
Eppley, Robert M. ;
Hines, Fred A. ;
Rorie, James ;
Ruggles, Dennis I. .
FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (06) :747-757
[3]   Critical effect sizes in toxicological risk assessment: a comprehensive and critical evaluation [J].
Dekkers, S ;
de Heer, C ;
Rennen, MAJ .
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2001, 10 (1-2) :33-52
[4]   Within-animal variation as an indication of the minimal magnitude of the critical effect size for continuous toxicological parameters applicable in the benchmark dose approach [J].
Dekkers, Susan ;
Telman, Jan ;
Rennen, Monique A. J. ;
Appel, Marco J. ;
Appel, Marco J. ;
de Heer, Cees .
RISK ANALYSIS, 2006, 26 (04) :867-880
[5]  
*EFSA, 2007, EFSAS 6 SCI C REP RI
[6]   Chronic feeding study of deoxynivalenol in B6C3F1 male and female mice [J].
Iverson, F ;
Armstrong, C ;
Nera, E ;
Truelove, J ;
Fernie, S ;
Scott, P ;
Stapley, R ;
Hayward, S ;
Gunner, S .
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 1995, 15 (06) :283-306
[7]   EMBRYOTOXICITY OF 4-DEOXYNIVALENOL (VOMITOXIN) IN MICE [J].
KHERA, KS ;
WHALEN, C ;
ANGERS, G ;
VESONDER, RF ;
KUIPERGOODMAN, T .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1982, 29 (04) :487-491
[8]  
Kistemaker C., 1998, V98812 TNO
[9]   Development of acute exposure guideline levels for airborne exposures to hazardous substances [J].
Krewski, D ;
Bakshi, K ;
Garrett, R ;
Falke, E ;
Rusch, G ;
Gaylor, D .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2004, 39 (02) :184-201
[10]   Comparison of human health risks resulting from exposure to fungicides and mycotoxins via food [J].
Muri, Stefan D. ;
van der Voet, Hilko ;
Boon, Polly E. ;
van Klaveren, Jacob D. ;
Brueschweiler, Beat J. .
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (12) :2963-2974