With the benefit of hindsight

被引：29

作者：

Milstein, C ^{[1
]}

机构：

[1] MRC Ctr, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(00)01660-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of a method to produce a monoclonal antibodies against a defined antigen has had profound impact in many branches of research and signalled a shift in the analysis of biological problems. This article describes the background to these developments and their important practical applications that impinge on the relationship between the world of basic science and commerce.

引用

收藏

页码：359 / 364

页数：8

相关论文

共 33 条

[1]

BARCLAY AN, 1993, LEUKOCYTE ANTIGEN FA

[2] AN APPROACH TO MAPPING OF ANTIGENS ON CELL SURFACE [J].

BOYSE, EA ;

OLD, LJ ;

STOCKERT, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 60 (03) :886-&

[3] FUSION OF 2 IMMUNOGLOBULIN-PRODUCING MYELOMA CELLS [J].

COTTON, RGH ;

MILSTEIN, C .

NATURE, 1973, 244 (5410) :42-43

[4] ANTIBODIES TO MAJOR HISTOCOMPATIBILITY ANTIGENS PRODUCED BY HYBRID CELL LINES [J].

GALFRE, G ;

HOWE, SC ;

MILSTEIN, C ;

BUTCHER, GW ;

HOWARD, JC .

NATURE, 1977, 266 (5602) :550-552

[5] RAT-X-RAT HYBRID MYELOMAS AND A MONOCLONAL ANTI-FD PORTION OF MOUSE IGG [J].

GALFRE, G ;

MILSTEIN, C ;

WRIGHT, B .

NATURE, 1979, 277 (5692) :131-133

[6] SOMATIC MUTATION AND THE MATURATION OF IMMUNE-RESPONSE TO 2-PHENYL OXAZOLONE [J].

GRIFFITHS, GM ;

BEREK, C ;

KAARTINEN, M ;

MILSTEIN, C .

NATURE, 1984, 312 (5991) :271-275

[7] MONOCLONAL ANTIBODIES AS TOOLS TO ANALYZE THE SEROLOGICAL AND GENETIC COMPLEXITIES OF MAJOR TRANSPLANTATION ANTIGENS [J].

HOWARD, JC ;

BUTCHER, GW ;

GALFRE, G ;

MILSTEIN, C ;

MILSTEIN, CP .

IMMUNOLOGICAL REVIEWS, 1979, 47 :139-174

[8]

Jakobovits A, 1995, ANN NY ACAD SCI, V764, P525

[9] REPLACING THE COMPLEMENTARITY-DETERMINING REGIONS IN A HUMAN-ANTIBODY WITH THOSE FROM A MOUSE [J].

JONES, PT ;

DEAR, PH ;

FOOTE, J ;

NEUBERGER, MS ;

WINTER, G .

NATURE, 1986, 321 (6069) :522-525

[10] MESSENGER-RNA SEQUENCES DEFINE AN UNUSUALLY RESTRICTED IGG RESPONSE TO 2-PHENYLOXAZOLONE AND ITS EARLY DIVERSIFICATION [J].

KAARTINEN, M ;

GRIFFITHS, GM ;

MARKHAM, AF ;

MILSTEIN, C .

NATURE, 1983, 304 (5924) :320-324

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