With the benefit of hindsight

被引：29

作者：

Milstein, C ^{[1
]}

机构：

[1] MRC Ctr, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(00)01660-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of a method to produce a monoclonal antibodies against a defined antigen has had profound impact in many branches of research and signalled a shift in the analysis of biological problems. This article describes the background to these developments and their important practical applications that impinge on the relationship between the world of basic science and commerce.

引用

页码：359 / 364

页数：8

共 33 条

[11] STABLE EXPRESSION AND SOMATIC HYPERMUTATION OF ANTIBODY-V REGIONS IN B-CELL DEVELOPMENTAL PATHWAYS [J].

KOCKS, C ;

RAJEWSKY, K .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :537-559

[12] CONTINUOUS CULTURES OF FUSED CELLS SECRETING ANTIBODY OF PREDEFINED SPECIFICITY [J].

KOHLER, G ;

MILSTEIN, C .

NATURE, 1975, 256 (5517) :495-497

[13]

LOCKEN MR, 1975, ANN NY ACAD SCI, V254, P163

[14] HUMAN THYMOCYTE ANTIGEN DEFINED BY A HYBRID MYELOMA MONOCLONAL ANTIBODY [J].

MCMICHAEL, AJ ;

PILCH, JR ;

GALFRE, G ;

MASON, DY ;

FABRE, JW ;

MILSTEIN, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1979, 9 (03) :205-210

[15] THE CROONIAN LECTURE, 1989 - ANTIBODIES - A PARADIGM FOR THE BIOLOGY OF MOLECULAR RECOGNITION [J].

MILSTEIN, C .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1990, 239 (1294) :1-16

[16]

Milstein C, 1999, BIOESSAYS, V21, P966, DOI 10.1002/(SICI)1521-1878(199911)21:11<966::AID-BIES9>3.3.CO

[17]

2-Q

[18] HYBRID HYBRIDOMAS AND THEIR USE IN IMMUNOHISTOCHEMISTRY [J].

MILSTEIN, C ;

CUELLO, AC .

NATURE, 1983, 305 (5934) :537-540

[19]

MILSTEIN C, 1982, MIAMI WINTER S P, V19, P3

[20]

MILSTEIN C, 1980, SCI AM, V243, P56

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