Synthesis and activity of 2,6,9-trisubstituted purines

被引:75
作者
Schow, SR [1 ]
Mackman, RL [1 ]
Blum, CL [1 ]
Brooks, E [1 ]
Horsma, AG [1 ]
Joly, A [1 ]
Kerwar, SS [1 ]
Lee, G [1 ]
Shiffman, D [1 ]
Nelson, MG [1 ]
Wang, XB [1 ]
Wick, MM [1 ]
Zhang, XM [1 ]
Lum, RT [1 ]
机构
[1] CV THERAPEUT INC, PALO ALTO, CA 94304 USA
关键词
D O I
10.1016/S0960-894X(97)10076-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The preparation of a series of 2,6,9-trisubstituted purines and the structure-activity data for the inhibition of cyclin dependent kinase, CDK2 are presented. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:2697 / 2702
页数:6
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