Tamoxifen-induced severe hypertriglyceridemia and pancreatitis

被引：47

作者：

Elisaf, MS ^{[1
]}

Nakou, K ^{[1
]}

Liamis, G ^{[1
]}

Pavlidis, NA ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece

来源：

ANNALS OF ONCOLOGY | 2000年 / 11卷 / 08期

关键词：

hypertriglyceridemia; pancreatitis; tamoxifen;

D O I：

10.1023/A:1008309613082

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tamoxifen exhibits favorable effects on the lipid and lipoprotein profile since it decreases the total and LDL cholesterol levels as well as the Lp(a) levels. Additionally, a small increase in serum triglycerides is commonly found after tamoxifen administration. However, severe hypertriglyceridemia which can sometimes be associated with life-threatening complications is occasionally noticed. Herein, we describe a patient who developed tamoxifen-induced severe hypertriglyceridemia and pancreatitis. An analysis of the underlying pathogenetic mechanisms as well as a review of the relevant literature is also provided.

引用

页码：1067 / 1069

页数：3

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