Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial

被引：73

作者：

Brueckner, RP ^{[1
]}

Coster, T

Wesche, DL

Shmuklarsky, M

Schuster, BG

机构：

[1] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Pharmacol, Div Expt Therapeut, Washington, DC 20307 USA

[2] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Washington, DC 20307 USA

[3] USA, Med Res Inst Infect Dis, Clin Studies Branch, Frederick, MD 21702 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 05期

关键词：

D O I：

10.1128/AAC.42.5.1293

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria.

引用

页码：1293 / 1294

页数：2

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