Mechanisms and molecules of the mitotic spindle

被引：259

作者：

Gadde, S ^{[1
]}

Heald, R ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 18期

关键词：

D O I：

10.1016/j.cub.2004.09.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and stability. Recent work has begun to uncover the molecular mechanisms behind these dynamic events. Here we describe current models and discuss some of the complex repertoire of factors required for spindle assembly and chromosome segregation.

引用

页码：R797 / R805

页数：9

共 90 条

[1] Aurora B regulates MCAK at the mitotic centromere [J].

Andrews, PD ;

Ovechkina, Y ;

Morrice, N ;

Wagenbach, M ;

Duncan, K ;

Wordeman, L ;

Swedlow, JR .

DEVELOPMENTAL CELL, 2004, 6 (02) :253-268

[2] REAL-TIME VISUALIZATION OF CELL-CYCLE DEPENDENT CHANGES IN MICROTUBULE DYNAMICS IN CYTOPLASMIC EXTRACTS [J].

BELMONT, LD ;

HYMAN, AA ;

SAWIN, KE ;

MITCHISON, TJ .

CELL, 1990, 62 (03) :579-589

[3] Spindle self-organization and cytokinesis during male meiosis in asterless mutants of Drosophila melanogaster [J].

Bonaccorsi, S ;

Giansanti, MG ;

Gatti, M .

JOURNAL OF CELL BIOLOGY, 1998, 142 (03) :751-761

[4] Microtubule flux and sliding in mitotic spindles of Drosophila embryos [J].

Brust-Mascher, I ;

Scholey, JM .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (11) :3967-3975

[5] Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis [J].

Bucciarelli, E ;

Giansanti, MG ;

Bonaccorsi, S ;

Gatti, M .

JOURNAL OF CELL BIOLOGY, 2003, 160 (07) :993-999

[6]

CASSIMERIS L, 1991, J CELL SCI, V98, P151

[7] The oncoprotein 18/stathmin family of microtubule destabilizers [J].

Cassimeris, L .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (01) :18-24

[8] Accessory protein regulation of microtubule dynamics throughout the cell cycle [J].

Cassimeris, L .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (01) :134-141

[9] A new kinesin tree [J].

Dagenbach, EM ;

Endow, SA .

JOURNAL OF CELL SCIENCE, 2004, 117 (01) :3-7

[10] Microtubule polymerization dynamics [J].

Desai, A ;

Mitchison, TJ .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :83-117

← 1 2 3 4 5 6 7 8 9 →