Mechanisms and molecules of the mitotic spindle

被引：261

作者：

Gadde, S ^{[1
]}

Heald, R ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 18期

关键词：

D O I：

10.1016/j.cub.2004.09.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and stability. Recent work has begun to uncover the molecular mechanisms behind these dynamic events. Here we describe current models and discuss some of the complex repertoire of factors required for spindle assembly and chromosome segregation.

引用

页码：R797 / R805

页数：9

共 90 条

[31] Microtubule nucleation [J].

Job, D ;

Valiron, O ;

Oakley, B .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (01) :111-117

[32] Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts [J].

Kalab, P ;

Weis, K ;

Heald, R .

SCIENCE, 2002, 295 (5564) :2452-2456

[33] Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix [J].

Kapoor, TM ;

Mitchison, TJ .

JOURNAL OF CELL BIOLOGY, 2001, 154 (06) :1125-1133

[34] Cytoplasmic dynein and dynactin in cell division and intracellular transport [J].

Karki, S ;

Holzbaur, ELF .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (01) :45-53

[35] Centrosome-independent mitotic spindle formation in vertebrates [J].

Khodjakov, A ;

Cole, RW ;

Oakley, BR ;

Rieder, CL .

CURRENT BIOLOGY, 2000, 10 (02) :59-67

[36] Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression [J].

Khodjakov, A ;

Rieder, CL .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :237-242

[37] Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis [J].

Khodjakov, A ;

Copenagle, L ;

Gordon, MB ;

Compton, DA ;

Kapoor, TM .

JOURNAL OF CELL BIOLOGY, 2003, 160 (05) :671-683

[38] Reconstitution of physiological microtubule dynamics using purified components [J].

Kinoshita, K ;

Arnal, I ;

Desai, A ;

Drechsel, DN ;

Hyman, AA .

SCIENCE, 2001, 294 (5545) :1340-1343

[39] BEYOND SELF-ASSEMBLY - FROM MICROTUBULES TO MORPHOGENESIS [J].

KIRSCHNER, M ;

MITCHISON, T .

CELL, 1986, 45 (03) :329-342

[40] Human TPX2 is required for targeting Aurora-A kinase to the spindle [J].

Kufer, TA ;

Silljé, HHW ;

Körner, R ;

Gruss, OJ ;

Meraldi, P ;

Nigg, EA .

JOURNAL OF CELL BIOLOGY, 2002, 158 (04) :617-623

← 1 2 3 4 5 6 7 8 9 →