Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation

被引：26

作者：

Abdelazim, Aaser ^{[1
,6
]}

Khater, Safaa ^{[1
]}

Ali, Haytham ^{[1
,3
]}

Shalaby, Shimaa ^{[2
]}

Afifi, Mohamed ^{[1
,3
,5
]}

Saddick, Salina ^{[4
]}

Alkaladi, Ali ^{[3
]}

Almaghrabi, Omar A. ^{[3
]}

机构：

[1] Zagazig Univ, Fac Vet Med, Dept Biochem, Zagazig, Egypt

[2] Zagazig Univ, Fac Vet Med, Dept Physiol, Zagazig, Egypt

[3] Univ Jeddah, Fac Sci, Dept Biol Sci, Jeddah, Saudi Arabia

[4] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, POB 80203, Jeddah 21589, Saudi Arabia

[5] Univ Jeddah, Ctr Sci & Med Res, Jeddah, Saudi Arabia

[6] Univ Bisha, Coll Appl Med Sci, Dept Basic Med Sci, Bisha, Saudi Arabia

来源：

SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2019年 / 26卷 / 07期

关键词：

AMPK; Diabetes mellitus; Ginseng; GLUT2; Insulin; KOREAN RED GINSENG; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; ANTIDIABETIC ACTIVITY; HEPATIC STEATOSIS; FAT ACCUMULATION; LIPID-METABOLISM; EXTRACT; DYSFUNCTION; SECRETION;

D O I：

10.1016/j.sjbs.2018.06.001

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

5' AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus. In this study, the effect of Panax ginseng was assessed on glucose manipulating enzymes activities and gene expression of AMPK, IRA and GLUT2 in streptozotocin-induced diabetic male rats. Forty male albino rats were randomly divided to four groups 10 rats of each, group I, normal control group (received saline orally); group II, normal rats received 200 mg/kg of Panax ginseng orally; group III, Streptozotocin (STZ)-induced diabetic rats and group IV, STZ-induced diabetic rats received 200 mg/kg of Panax ginseng orally. The duration of experiment was 30 days. Results showed the ability of Panax ginseng to induce a significant decrease in the blood glucose and increase in the serum insulin levels, hepatic glucokinase (GK), and glycogen synthase (GS) activities with a modulation of lipid profile besides high expression levels of AMPK, insulin receptor A (IRA), glucose transporting protein-2 (GLUT-2) in liver of diabetic rats. In conclusion, the obtained results point to the ability of Panax ginseng to improve the glucose metabolism in diabetic models. (C) 2018 Production and hosting by Elsevier B.V.

引用

页码：1436 / 1441

页数：6

共 73 条

[1]

Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin- Induced Diabetic Rats [J].