α-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population

被引：24

作者：

Ezquerra, M

Blesa, R

Tolosa, E

Ballesta, F

Oliva, R

机构：

[1] Hosp Clin & Prov, Genet Serv, Barcelona 08036, Spain

[2] Univ Barcelona, E-08036 Barcelona, Spain

[3] Hosp Clin & Prov, Neurol Serv, Barcelona 08036, Spain

来源：

NEUROSCIENCE LETTERS | 1998年 / 240卷 / 02期

关键词：

Alzheimer's disease; alpha-antichymotrypsin; alpha-antichymotrypsin polymorphism; genes; apolipoprotein E; ApoE;

D O I：

10.1016/S0304-3940(97)00924-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The alpha-antichymotrypsin (ACT) and the ApoE polymorphisms have been determined in 136 Alzheimer's disease (AD) patients and in 92 age-matched controls. Only a borderline significant difference is found when comparing the overall ACT/AA genotype frequency between AD patients and controls (chi(2), P = 0.08). However this difference is attributable entirely and significantly to the ApoE epsilon 4 non-carrier AD group (chi(2), P = 0.004). No differences are found in the ACT/AA genotype frequency of the ApoE epsilon 4 AD carrier group as compared controls (chi(2), P = 0.98) in contrast with previous works. These findings support that the presence of the ACT/AA genotype is a genetic risk factor for developing AD in non-ApoE epsilon 4 carriers subjects in our population. (C) 1998 Elsevier Science Ireland Ltd.

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收藏

页码：107 / 109

页数：3

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