Regional and cellular Presenilin 1 gene expression in human and rat tissues

被引：72

作者：

Suzuki, T ^{[1
]}

Nishiyama, K ^{[1
]}

Murayama, S ^{[1
]}

Yamamoto, A ^{[1
]}

Sato, S ^{[1
]}

Kanazawa, I ^{[1
]}

Sakaki, Y ^{[1
]}

机构：

[1] UNIV TOKYO, SCH MED, DEPT NEUROL, INST BRAIN RES, BUNKO KU, TOKYO 113, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presenilin 1 (PSNL1) is a novel causative gene for early-onset familial Alzheimer's disease (EOFAD). We have examined the regional and cellular distribution of PSLN1 gene expression in normal human and rat tissues. In situ hybridization and Northern blot analysis showed that PSNL1 mRNA was ubiquitously expressed in many different organs. We also demonstrated that PSNL1 mRNA was expressed predominantly in the neuronal cells of the central nervous system, but only at low-level in glial cells. Furthermore, the distribution of PSNL1 mRNA in human and rodent brains was similar. (C) 1996 Academic Press, Inc.

引用

页码：708 / 713

页数：6

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