Why men's hearts break: Cardiovascular effects of sex steroids

被引：42

作者：

Choi, Brian G. ^{[1
]}

McLaughlin, Mary Ann ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2007年 / 36卷 / 02期

关键词：

D O I：

10.1016/j.ecl.2007.03.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.

引用

页码：365 / +

页数：14

共 99 条

[81] Low testosterone levels are associated with carotid atherosclerosis in men [J].

Svartberg, J. ;

Von Muehlen, D. ;

Mathiesen, E. ;

Joakimsen, O. ;

Bonaa, K. H. ;

Stensland-Bugge, E. .

JOURNAL OF INTERNAL MEDICINE, 2006, 259 (06) :576-582

[82] Waist circumference and testosterone levels in community dwelling men. The Tromsø study [J].

Svartberg J. ;

Von Mühlen D. ;

Sundsfjord J. ;

Jorde R. .

European Journal of Epidemiology, 2004, 19 (7) :657-663

[83] The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromso Study [J].

Svartberg, J ;

Jenssen, T ;

Sundsfjord, J ;

Jorde, R .

DIABETES & METABOLISM, 2004, 30 (01) :29-34

[84] Mortality in patients with Klinefelter syndrome in Britain: A cohort study [J].

Swerdlow, AJ ;

Higgins, CD ;

Schoemaker, MJ ;

Wright, AF ;

Jacobs, PA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (12) :6516-6522

[85]

Tamaki T, 2001, AM J PHYSIOL-ENDOC M, V280, pE973

[86] Heart disease and stroke statistics - 2006 update - A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee [J].

Thom, T ;

Haase, N ;

Rosamond, W ;

Howard, VJ ;

Rumsfeld, J ;

Manolio, T ;

Zheng, ZJ ;

Flegal, K ;

O'Donnell, C ;

Kittner, S ;

Lloyd-Jones, D ;

Goff, DC ;

Hong, YL ;

Adams, R ;

Friday, G ;

Furie, K ;

Gorelick, P ;

Kissela, B ;

Marler, J ;

Meigs, J ;

Roger, V ;

Sidney, S ;

Sorlie, P ;

Steinberger, J ;

Wasserthiel-Smoller, S ;

Wilson, M ;

Wolf, P .

CIRCULATION, 2006, 113 (06) :E85-E151

[87] Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population [J].

Tilvis, RS ;

Kähönen, M ;

Härkönen, M .

AGING CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 11 (01) :30-34

[88] Dehydroepiandrosterone sulfate and mortality in elderly men and women [J].

Trivedi, DP ;

Khaw, KT .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) :4171-4177

[89] Endogenous hormones and carotid atherosclerosis in elderly men [J].

van den Beld, AW ;

Bots, ML ;

Janssen, JAMLL ;

Pols, HAP ;

Lamberts, SWJ ;

Grobbee, DE .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (01) :25-31

[90]

VANZYL CG, 1995, MED SCI SPORT EXER, V27, P1385

← 1 2 3 4 5 6 7 8 9 10 →