Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension

被引：23

作者：

Rezkalla, SH

Hayes, JJ

Curtis, BR

Aster, RH

机构：

[1] Marshfield Clin Fdn Med Res & Educ, Dept Cardiol, Marshfield, WI 54449 USA

[2] Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA

[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS | 2003年 / 58卷 / 01期

关键词：

IIb/IIIa receptors; interventional cardiology; eptifibatide antibodies;

D O I：

10.1002/ccd.10392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.

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收藏

页码：76 / 79

页数：4

相关论文

共 9 条

[1] Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated [J].

Billheimer, JT ;

Dicker, IB ;

Wynn, R ;

Bradley, JD ;

Cromley, DA ;

Godonis, HE ;

Grimminger, LC ;

He, BK ;

Kieras, CJ ;

Pedicord, DL ;

Spitz, SM ;

Thomas, BE ;

Zolotarjova, NI ;

Gorko, MA ;

Hollis, GF ;

Daly, RN ;

Stern, AM ;

Seiffert, D .

BLOOD, 2002, 99 (10) :3540-3546

[2]

BOUGIE DW, IN PRESS BLOOD

[3] ANTIBODIES IN SULFONAMIDE-INDUCED IMMUNE THROMBOCYTOPENIA RECOGNIZE CALCIUM-DEPENDENT EPITOPES ON THE GLYCOPROTEIN IIB/IIIA COMPLEX [J].

CURTIS, BR ;

MCFARLAND, JG ;

WU, GG ;

VISENTIN, GP ;

ASTER, RH .

BLOOD, 1994, 84 (01) :176-183

[4] Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: A pooled analysis [J].

Dasgupta, H ;

Blankenship, JC ;

Wood, GC ;

Frey, CM ;

Demko, SL ;

Menapace, FJ .

AMERICAN HEART JOURNAL, 2000, 140 (02) :206-211

[5] Concurrence of anaphylaxis and acute heparin-induced thrombocytopenia in a patient with heparin-induced antibodies [J].

Hewitt, RL ;

Akers, DL ;

Leissinger, CA ;

Gill, JI ;

Aster, RH .

JOURNAL OF VASCULAR SURGERY, 1998, 28 (03) :561-565

[6] Association of eptifibatide and acute profound thrombocytopenia [J].

Hongo, RH ;

Brent, BN .

AMERICAN JOURNAL OF CARDIOLOGY, 2001, 88 (04) :428-+

[7] Understanding thrombocytopenia and antigenicity with glycoprotein IIb-IIIa inhibitors [J].

Madan, M ;

Berkowitz, SD .

AMERICAN HEART JOURNAL, 1999, 138 (04) :S317-S326

[8] Severe thrombocytopenia possibly related to readministration of eptifibatide [J].

Paradiso-Hardy, FL ;

Madan, M ;

Radhakrishnan, S ;

Hurden, S ;

Cohen, EA .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2001, 54 (01) :63-67

[9] Platelet activation as a potential mechanism of GP IIb/IIIa inhibitor-induced thrombocytopenia [J].

Peter, K ;

Straub, A ;

Kohler, B ;

Volkmann, M ;

Schwarz, M ;

Kübler, W ;

Bode, C .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 84 (05) :519-524