EMT: 2016

被引：4497

作者：

Angela Nieto, M. ^{[1
]}

Huang, Ruby Yun-Ju ^{[2
,3
]}

Jackson, Rebecca A. ^{[4
]}

Thiery, Jean Paul ^{[3
,4
,5
]}

机构：

[1] Inst Neurociencias CSIC UMH, Avda Ramon y Cajal S-N, Alacant 03550, Spain

[2] Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore 119228, Singapore

[3] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore

[5] ASTAR, Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

CELL | 2016年 / 166卷 / 01期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM-CELLS; CIRCULATING TUMOR-CELLS; HEPATIC STELLATE CELLS; E-CADHERIN REPRESSION; SRC-KINASE INHIBITOR; HEAT-SHOCK PROTEINS; NEURAL CREST CELLS; GROWTH-FACTOR-BETA; BREAST-CANCER;

D O I：

10.1016/j.cell.2016.06.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The significant parallels between cell plasticity during embryonic development and carcinoma progression have helped us understand the importance of the epithelial-mesenchymal transition (EMT) in human disease. Our expanding knowledge of EMT has led to a clarification of the EMT program as a set of multiple and dynamic transitional states between the epithelial and mesenchymal phenotypes, as opposed to a process involving a single binary decision. EMT and its intermediate states have recently been identified as crucial drivers of organ fibrosis and tumor progression, although there is some need for caution when interpreting its contribution to metastatic colonization. Here, we discuss the current state-of-the-art and latest findings regarding the concept of cellular plasticity and heterogeneity in EMT. We raise some of the questions pending and identify the challenges faced in this fast-moving field.

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页码：21 / 45

页数：25

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