Synthesis and thermo-physical properties of chitosan/poly(DL-lactide-co-glycolide) composites prepared by thermally induced phase separation

被引：48

作者：

Adriana Martel-Estrada, Santos ^{[1
]}

Alberto Martinez-Perez, Carlos ^{[2
]}

Guadalupe Chacon-Nava, Jose ^{[1
]}

Elvia Garcia-Casillas, Perla ^{[2
]}

Olivas-Armendariz, Imelda ^{[2
]}

机构：

[1] Ctr Invest Mat Avanzados, Dept Fis Mat, Chihuahua 31109, Mexico

[2] Univ Autonoma de Cd Juarez, Inst Ingn & Tecnol, Mexico City, DF, Mexico

来源：

CARBOHYDRATE POLYMERS | 2010年 / 81卷 / 04期

关键词：

Chitosan; Poly(DL-lactide-co-glycolide); Scaffold; Thermal properties; Thermally induced phase separation; POROUS SCAFFOLDS; FREEZE-GELATION; CHITOSAN; DEGRADATION; MATRIX; POLY(D; DMA;

D O I：

10.1016/j.carbpol.2010.03.032

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Chitosan and poly(DL-lactide-co-glycolide)(DLPLG) were used to fabricate biodegradable porous scaffolds for applications in tissue engineering by thermally induced phase separation (TIPS) technique. Parameters such as polymer concentration, quenching temperature, solvent ratio and different compositions were analyzed. Aqueous glacial acetic acid solution was used as a solvent for chitosan and chloroform for the lactide part. Through the use of a field emission scanning electron microscopy, the variation in porous morphology was studied. The cumulative results obtained from IR and X-ray diffraction spectra, TGA, DSC and DMA suggest that there is a chemical interaction between the components of the composite. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：775 / 783

页数：9

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