Direct Synthesis of Imines from Alcohols and Amines with Liberation of H2

被引：422

作者：

Gnanaprakasam, Boopathy ^{[1
]}

Zhang, Jing ^{[1
]}

Milstein, David ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 08期

基金：

以色列科学基金会;

关键词：

homogeneous catalysis; imines; pincer complexes; ruthenium; synthetic methods; ONE-POT SYNTHESIS; SECONDARY-AMINES; ELECTRON-RICH; RUTHENIUM COMPLEXES; BORROWING HYDROGEN; PINCER COMPLEX; DEHYDROGENATION; ACTIVATION; OXIDATION; SYSTEM;

D O I：

10.1002/anie.200907018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

"Chemical equation presented" A clean sweep: Aryl and aliphatic mines can be synthesized directly and efficiently from alcohols and amines under mild, neutral conditions with the liberation of only molecular hydrogen and water (see scheme; R=isopropyl, tert-butyl). This general, environmentally benign reaction is catalyzed by a de-aromatized ruthenium PNP pincer complex (0.2 mol%), and can proceed in toluene under an inert atmosphere or under air. © 2010 Wiley-VCH Verlag GmbH &. Co. KGaA.

引用

页码：1468 / 1471

页数：4