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Target cells in vaginal HIV transmission

被引：172
作者：
Miller, CJ
Shattock, RJ
机构：
[1] Univ Calif Davis, Sch Vet Med, Dept Vet Pathol Microbiol & Immunol, Ctr Comparat Med,Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[2] St George Hosp, Sch Med, Dept Infect Dis, London SW17 0RE, England
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 01期
关键词：
Langerhans cells; SIV; inflammation; epithelium;
D O I：
10.1016/S1286-4579(02)00056-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：59 / 67
页数：9
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