AMP-activated protein kinase and hepatic genes involved in glucose metabolism

被引：38

作者：

Ferré, P ^{[1
]}

Azzout-Marniche, D ^{[1
]}

Foufelle, F ^{[1
]}

机构：

[1] Ctr Rech Biomed Cordeliers, INSERM, U465, F-75270 Paris 06, France

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

forkhead-related protein; gluconeogenesis; hepatocyte nuclear factor 4 alpha; lipogenesis; sterol-regulatory-element-binding protein-1c;

D O I：

10.1042/bst0310220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.

引用

页码：220 / 223

页数：4

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