GeneXplorer: an interactive web application for microarray data visualization and analysis

被引:10
作者
Rees, CA
Demeter, J
Matese, JC
Botstein, D
Sherlock, G
机构
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
[3] Princeton Univ, Lewis Sigler Inst Integrat Genom Carl Icahn Lab, Princeton, NJ 08544 USA
关键词
D O I
10.1186/1471-2105-5-141
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Background: When publishing large-scale microarray datasets, it is of great value to create supplemental websites where either the full data, or selected subsets corresponding to figures within the paper, can be browsed. We set out to create a CGI application containing many of the features of some of the existing standalone software for the visualization of clustered microarray data. Results: We present GeneXplorer, a web application for interactive microarray data visualization and analysis in a web environment. GeneXplorer allows users to browse a microarray dataset in an intuitive fashion. It provides simple access to microarray data over the Internet and uses only HTML and JavaScript to display graphic and annotation information. It provides radar and zoom views of the data, allows display of the nearest neighbors to a gene expression vector based on their Pearson correlations and provides the ability to search gene annotation fields. Conclusions: The software is released under the permissive MIT Open Source license, and the complete documentation and the entire source code are freely available for download from CPAN http://search.cpan.org/dist/Microarray-GeneXplorer/.
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页数:7
相关论文
共 12 条
[1]   Open source clustering software [J].
de Hoon, MJL ;
Imoto, S ;
Nolan, J ;
Miyano, S .
BIOINFORMATICS, 2004, 20 (09) :1453-1454
[2]   SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data [J].
Diehn, M ;
Sherlock, G ;
Binkley, G ;
Jin, H ;
Matese, JC ;
Hernandez-Boussard, T ;
Rees, CA ;
Cherry, JM ;
Botstein, D ;
Brown, PO ;
Alizadeh, AA .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :219-223
[3]   Cluster analysis and display of genome-wide expression patterns [J].
Eisen, MB ;
Spellman, PT ;
Brown, PO ;
Botstein, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868
[4]  
Gasch AP, 2002, GENOME BIOL, V3
[5]   The Stanford Microarray Database: data access and quality assessment tools [J].
Gollub, J ;
Ball, CA ;
Binkley, G ;
Demeter, J ;
Finkelstein, DB ;
Hebert, JM ;
Hernandez-Boussard, T ;
Jin, H ;
Kaloper, M ;
Matese, JC ;
Schroeder, M ;
Brown, PO ;
Botstein, D ;
Sherlock, G .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :94-96
[6]   FGDP: functional genomics data pipeline for automated, multiple microarray data analyses [J].
Grant, JD ;
Somers, LA ;
Zhang, Y ;
Manion, FJ ;
Bidaut, G ;
Ochs, MF .
BIOINFORMATICS, 2004, 20 (02) :282-283
[7]   GEPAS:: a web-based resource for microarray gene expression data analysis [J].
Herrero, J ;
Al-Shahrour, F ;
Díaz-Uriarte, R ;
Mateos, A ;
Vaquerizas, JM ;
Santoyo, J ;
Dopazo, J .
NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3461-3467
[8]  
KRASNER GE, 1988, J OBJECT-ORIENT PROG, V1, P41
[9]   Gene expression profiling identifies clinically relevant subtypes of prostate cancer [J].
Lapointe, J ;
Li, C ;
Higgins, JP ;
van de Rijn, M ;
Bair, E ;
Montgomery, K ;
Ferrari, M ;
Egevad, L ;
Rayford, W ;
Bergerheim, U ;
Ekman, P ;
DeMarzo, AM ;
Tibshirani, R ;
Botstein, D ;
Brown, PO ;
Brooks, JD ;
Pollack, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :811-816
[10]   TM4: A free, open-source system for microarray data management and analysis [J].
Saeed, AI ;
Sharov, V ;
White, J ;
Li, J ;
Liang, W ;
Bhagabati, N ;
Braisted, J ;
Klapa, M ;
Currier, T ;
Thiagarajan, M ;
Sturn, A ;
Snuffin, M ;
Rezantsev, A ;
Popov, D ;
Ryltsov, A ;
Kostukovich, E ;
Borisovsky, I ;
Liu, Z ;
Vinsavich, A ;
Trush, V ;
Quackenbush, J .
BIOTECHNIQUES, 2003, 34 (02) :374-+