Bioresponsive nanosensors in medical imaging

被引：13

作者：

Schellenberger, Eyk ^{[1
]}

机构：

[1] Charite, Dept Radiol, D-10117 Berlin, Germany

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2010年 / 7卷

关键词：

apoptosis imaging; enzyme activity; superparamagnetic; matrix metalloproteinase; iron oxide particles; ANNEXIN-V SCINTIGRAPHY; IRON-OXIDE PARTICLES; IN-VIVO; MYOCYTE APOPTOSIS; CONTRAST-MEDIUM; CHEMOTHERAPY; DOSIMETRY; CANCER; TUMORS; AGENT;

D O I：

10.1098/rsif.2009.0336.focus

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Superparamagnetic iron oxide nanoparticles have been established as sensitive probes for magnetic resonance imaging (MRI). While the majority of specific nanosensors are based on sterically stabilized iron oxide particles, the focus of this review is on the use of very small iron oxide particles (VSOPs) that are electrostatically stabilized by an anionic citrate acid shell. We used VSOPs to develop target-specific as well as protease-activatable nanosensors for molecular MRI.

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收藏

页码：S83 / S91

页数：9

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