Antigenic and Genetic Diversity of Highly Pathogenic Avian Influenza A (H5N1) Viruses Isolated in Egypt

被引：55

作者：

Balish, Amanda L. ^{[1
]}

Davis, C. Todd ^{[1
]}

Saad, Magdi D. ^{[2
]}

El-Sayed, Nasr ^{[3
]}

Esmat, Hala ^{[3
]}

Tjaden, Jeffrey A. ^{[2
]}

Earhart, Kenneth C. ^{[2
]}

Ahmed, Lu'ay E. ^{[4
]}

Abd El-Halem, Mohamed ^{[4
]}

Ali, Abdel Hakem M. ^{[5
]}

Nassif, Samir A. ^{[5
]}

El-Ebiary, Elham A. ^{[5
]}

Taha, M. ^{[5
]}

Aly, Mona M. ^{[6
]}

Arafa, Abdelstattar ^{[6
]}

O'Neill, Eduardo ^{[1
]}

Xu Xiyan ^{[1
]}

Cox, Nancy J. ^{[1
]}

Donis, Ruben O. ^{[1
]}

Klimov, Alexander I. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA

[2] NAMRU 3 Cairo, Viral & Zoonot Dis Res Program, Cairo, Egypt

[3] Minist Hlth & Populat, Cairo, Egypt

[4] Minist Environm, Cairo, Egypt

[5] Cent Lab Evaluat Vet Biol, Cairo, Egypt

[6] Natl Lab Qual Control Poultry Prod, Cairo, Egypt

来源：

AVIAN DISEASES | 2010年 / 54卷 / 01期

关键词：

HPAI; H5N1; Egypt; clade; 2.2; pandemic; vaccine; OUTBREAKS; PCR;

D O I：

10.1637/8903-042909-Reg.1

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Highly pathogenic avian influenza A virus (H5N1) has diverged antigenically and genetically since its initial detection in Asia in 1997. Viruses belonging to clade 2.2 in particular have been reported in numerous countries with the majority occurring in Egypt. Previous reports identified antigenic similarities between viruses belonging to clack 2.2. However, poultry and human viruses isolated in northern Egypt during 2007 and 2008 were found to he antigenically distinct from other clade 2.2 viruses from this country. Genetic analysis of the hemagglutinin revealed a high degree of nucleotide and ammo acid divergence. The antigenic changes in Egyptian viruses isolated during 2007-08 necessitated that two of these strains be considered as potential H5N1 pre-pandemic vaccine candidates.

引用

页码：329 / 334

页数：6

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