Activity of telithromycin against erythromycin-susceptible and -resistant Streptococcus pneumoniae isolates from adults with invasive infections

被引：5

作者：

Ortega, M ^{[1
]}

Marco, F

Almela, M

Puig, J

Soriano, A

Mensa, J

机构：

[1] Hosp Clin Barcelona, Infect Dis Unit, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, Dept Microbiol, E-08036 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 24卷 / 06期

关键词：

telithromycin; bactericidal activity; time-kill curves; S; pneumoniae;

D O I：

10.1016/j.ijantimicag.2004.06.018

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A telithromycin (TEL) kill-kinetics study was conducted with 120 clinically significant Streptococcus pneurnoniae isolates (60 susceptible and 60 highly resistant to erythromycin). Time-kill curves were performed using different antibiotic concentrations. The minimum inhibitory concentrations (MICs) of TEL were low for both erythromycin-susceptible (MIC less than or equal to 0.0 16 mg/L) and erythromycin-resistant strains (MIC less than or equal to 0.25 mg/L). TEL showed 99.9% killing of all erythromycin resistant strains at 18-24 h of incubation. Even for strains with erythromycin MICs greater than or equal to 64.0 mg/L, TEL was uniformly bactericidal at 0.25 mg/L. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：616 / 618

页数：3

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