Dammarane saponins from Gynostemma pentaphyllum

被引：22

作者：

Hu, Yongmei ^{[1
]}

Ip, Fanny C. F. ^{[1
]}

Fu, Guangmiao ^{[1
]}

Pang, Haihong ^{[1
]}

Ye, Wencai ^{[2
]}

Ip, Nancy Y. ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Biotechnol Res Inst, Mol Neurosci Ctr, Kowloon, Hong Kong, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 10期

关键词：

Gynostemma pentaphyllum; Cucurbitaceae; Saponins; Cortical neurons; ERK phosphorylation; TRITERPENE SAPONINS; ENDOTHELIAL-CELLS; ALPHA ACTIVATOR; GYPENOSIDES; GLYCOSIDES; APOPTOSIS; PHOSPHORYLATION; EXPRESSION; MECHANISM; ISCHEMIA;

D O I：

10.1016/j.phytochem.2010.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dammarane-type saponins (1-7), together with five known compounds, were isolated from the aerial parts of Gynostemma pentaphyllum. Compounds 1-4,6 and 7 induced the phosphorylation of ERK protein in primary rat cortical neurons, which indicates their potential neuroactivity. On the other hand, no induction of ERK phosphorylation was observed for HEK293 cells following treatment with saponins 1, 3, 4 and 7. (C) 2010 Elsevier Ltd. All rights reserved.

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页码：1149 / 1157

页数：9

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