Polymorphisms in the TNFA promoter region is not associated with palmoplantar pustulosis

被引:13
作者
Niizeki, H
Naruse, T
Yokoyama, M
Yamasaki, Y
Akiya, K
Tojo, T
Urushibara, T
Yamazaki, Y
Inoko, H
Nishikawa, T
机构
[1] Natl Tokyo Med Ctr, Dept Dermatol, Meguro Ku, Tokyo 1528902, Japan
[2] Natl Tokyo Med Ctr, Inst Clin Res, Meguro Ku, Tokyo 1528902, Japan
[3] Tokai Univ, Sch Med, Dept Mol Lifesci, Kanagawa, Japan
[4] Kitasato Inst Hosp, Dept Otolaryngol, Tokyo, Japan
[5] Natl Tokyo Med Ctr, Dept Internal Med, Meguro Ku, Tokyo 1528902, Japan
[6] Kitasato Univ, Sch Pharmaceut Sci, Ctr Environm Management, Tokyo 108, Japan
[7] Keio Univ, Sch Med, Dept Dermatol, Tokyo, Japan
[8] Keio Univ, Sch Med, Dept Otolaryngol, Tokyo, Japan
来源
TISSUE ANTIGENS | 2000年 / 56卷 / 02期
关键词
palmoplantar pustulosis; TNFA; TNFB; single nucleotide polymorphism;
D O I
10.1034/j.1399-0039.2000.560209.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polymorphisms of the 5'-flanking promoter/enhancer region of the TNFA gene were determined in 80 Japanese patients with pulmoplantar pustulosis (PPP). The 5'-flanking region of the TNFA gene from -1107 to -66 was amplified by polymerase chain reaction (PCR) method. Nucleotide sequencing data from the PCR products revealed that 5 single nucleotide polymorphisms at position -1031, -863, -857, -307 and -237. None of the nucleotide substitutions were significantly increased in PPP patients when compared with those in controls. To clarify the linkage among the neighboring genetic marker, we analyzed the association between the polymorphisms in the TNFA promoter region and the NcoI polymorphism in the first intron of the TNFB gene as well as HLA-DR9. The genotype at -1031C is strongly associated with TNFB1 and negatively associated with TNFB2 which is reported to be associated with PPP. These data indicate that TNFA gene centromeric to TNFB is not associated with PPP and the susceptible gene of PPP is located between TNFB and HLA-B.
引用
收藏
页码:162 / 165
页数:4
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