Regulatory T cells in obesity: the leptin connection

被引：155

作者：

Matarese, Giuseppe ^{[1
,2
]}

Procaccini, Claudio ^{[1
,2
]}

De Rosa, Veronica ^{[1
,2
]}

Horvath, Tamas L. ^{[3
]}

La Cava, Antonio ^{[4
]}

机构：

[1] CNR, IEOS, Immunol Lab, I-80125 Naples, Italy

[2] Univ Napoli Federico II, Dipartimento Biol & Patol Cellulare Mol, Naples, Italy

[3] Yale Univ, Sch Med, Comparat Med Sect, Program Cell & Neurobiol Energy Metab, New Haven, CT 06510 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2010年 / 16卷 / 06期

关键词：

CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; DIET-INDUCED OBESITY; BLOOD-BRAIN-BARRIER; EARLY-ONSET OBESITY; IMMUNOLOGICAL-TOLERANCE; OXIDATIVE STRESS; IMMUNE-RESPONSE; PROTECTS MICE; RECEPTOR;

D O I：

10.1016/j.molmed.2010.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies to understand the pathogenesis of obesity have revealed mediators that are responsible for the control of food intake and metabolism at the hypothalamic level. However, molecular insight explaining the link between obesity and low-degree chronic inflammation remains elusive. The adipocyte-derived hormone leptin, and thereby the nutritional status, could control immune self-tolerance by affecting regulatory T (Treg) cell responsiveness and function. Furthermore, resident Treg cells, which are capable of modulating metabolism and glucose homeostasis, are abundant in adipose tissue. Here, we provide an update on recent findings relating Treg cells to obesity and discuss how the intricate network of interactions among leptin, Treg cells and adipose tissue might provide new strategies for therapeutic interventions.

引用

页码：247 / 256

页数：10

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